The College of Science and Technology was established to lead research and education in natural science, applied science, and computer technology.

Science and technology education that started with the foundation of divisions in mathematics, physics, chemistry, and biology on the Wonju Campus in 1981 grew considerably as it was included in the College of Liberal Arts and Sciences in 1984. In 1989, it expanded with the inclusion of statistics (currently information and statistics), computation (currently computer information and communications), and dairy farming (currently applied biotechnology). In 2001, it was the first among Korean universities to establish a packaged division. As the College of Liberal Arts and Sciences split into two in March 2007, it became an independent college.

The College of Science and Technology is located in the Creativity Hall of Wonju Campus, which possesses modern science education and research facilities. The college is actively carrying out research and education for businesses nationwide and for individual regions. Currently, it consists of the Division of Natural Sciences, the Division of Biotechnology, the Division of Applied Sciences, and the Division of Computer and Telecommunication Engineering.

The Division of Natural Sciences has five departments: Mathematics, Physics, Chemistry, Life Science, Information and Statistics. The Division of Applied Sciences has two departments: Biotechnology and Applied Biotechnology. The Computer and Telecommunications Engineering Division is composed of computer engineering area and telecommunications engineering area.

The college has around 50 of the most prominent faculty members in Korea, and provides not only undergraduate courses but also graduate and post-graduate courses. In addition, institutes for basic science and bio-new-materials were established to facilitate the joint research of professors in similar divisions. The institutes are conducting research for Korean and foreign entities. In particular, chemistry and life sciences were designated as a part of the BK21 in 2006, and the college is actively working to attract state-funded research, including the Nuri business.

The College of Science and Technology will lead the development of science and technology in Korea by nurturing talents with expertise, creativity, responsibility, as well as adaptive ability regarding globalization.